Inhibitors | Comment | Organism | Structure |
---|---|---|---|
(1R,2R)-1-(4-chlorobenzyl)-2-phenylcyclopropanecarboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
(1R,2R)-1-(4-methylbenzyl)-2-phenylcyclopropanecarboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
(1R,2R)-1-benzyl-2-phenylcyclopropanecarboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
(1R,2S)-1-ethyl-2-phenylcyclopropanecarboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
(1S,2R)-1-ethyl-2-phenylcyclopropanecarboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
(1S,2S)-1-(4-chlorobenzyl)-2-phenylcyclopropanecarboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
(1S,2S)-1-(4-methylbenzyl)-2-phenylcyclopropanecarboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
(1S,2S)-1-benzyl-2-phenylcyclopropanecarboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
additional information | computational and spectroscopic approaches to rationally design, synthesize, and test a series of substituted 2-phenylcyclopropane carboxylic acids that bind to the two Salmonella typhymurium OASS isoforms at nanomolar concentrations, Kd values and binding structures, molecular modeling and docking study, overview; computational and spectroscopic approaches to rationally design, synthesize, and test a series of substituted 2-phenylcyclopropane carboxylic acids that bind to the two Salmonella typhymurium OASS isoforms at nanomolar concentrations, Kd values and binding structures, molecular modeling and docking study, overview | Salmonella enterica subsp. enterica serovar Typhimurium | |
trans-1-(4-chlorobenzyl)-2-phenylcyclopropanecarboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
trans-1-(4-methylbenzyl)-2-phenylcyclopropanecarboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
trans-1-benzyl-2-phenylcyclopropanecarboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
trans-1-ethyl-2-phenylcyclopropanecarboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
trans-1-phenethyl-2-phenylcyclopropanecarboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium | |
trans-2-phenylcyclopropanecarboxylic acid | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
O-acetyl-L-serine + hydrogen sulfide | Salmonella enterica subsp. enterica serovar Typhimurium | - |
L-cysteine + acetate | - |
? | |
O-acetyl-L-serine + hydrogen sulfide | Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | - |
L-cysteine + acetate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Salmonella enterica subsp. enterica serovar Typhimurium | P0A1E3 | isozyme OASS-A | - |
Salmonella enterica subsp. enterica serovar Typhimurium | P29848 | isozyme OASS-B | - |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | P0A1E3 | isozyme OASS-A | - |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | P29848 | isozyme OASS-B | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
O-acetyl-L-serine + hydrogen sulfide | - |
Salmonella enterica subsp. enterica serovar Typhimurium | L-cysteine + acetate | - |
? | |
O-acetyl-L-serine + hydrogen sulfide | - |
Salmonella enterica subsp. enterica serovar Typhimurium ATCC 700720 | L-cysteine + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cysK | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
CysM | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
cysteine synthase A | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
cysteine synthase B | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
O-acetylserine sulfhydrylase | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
OASS | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
20 | 25 | assay at | Salmonella enterica subsp. enterica serovar Typhimurium |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Salmonella enterica subsp. enterica serovar Typhimurium |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
pyridoxal 5'-phosphate | dependent on | Salmonella enterica subsp. enterica serovar Typhimurium |
General Information | Comment | Organism |
---|---|---|
evolution | O-acetylserine sulfydrylase, a highly conserved pyridoxal 5'-phosphate-dependent enzyme, present in different isoforms in bacteria, plants, and nematodes, but absent in mammals | Salmonella enterica subsp. enterica serovar Typhimurium |
metabolism | the enzyme catalyzes the last step of cysteine biosynthesis. Cysteine is a building block for several biomolecules that are crucial for living organisms | Salmonella enterica subsp. enterica serovar Typhimurium |
physiological function | beside the biosynthesis of cysteine, enzyme OASS exerts a series of moonlighting activities in bacteria, such as transcriptional regulation, contact-dependent growth inhibition, swarming motility, and induction of antibiotic resistance | Salmonella enterica subsp. enterica serovar Typhimurium |